Hundreds of fans gathered to watch on a big screen in Melbourne – the city where the show is set and produced.
In the UK, where Neighbours found most success, the finale will be broadcast on Friday evening on Channel 5.
Former stars of the show including Kylie Minogue, Jason Donovan, Guy Pearce and Margot Robbie returned to say goodbye to Ramsay Street.
Over almost 37 years, the soap has had plane crashes, bushfires, drownings, and several tearful bedside death scenes.
But while we won’t be giving away plot spoilers for the UK audience, the show’s producers had been clear they wouldn’t end on scenes of destruction and devastation.